We hypothesize that the TET2- and PTPN11-related animals manifest features of FAB_M4/M5 rather than FAB_M0/M1/M2 since they are also hot mutations in chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia (CMML and JMML). The gene discussed is PTPN11; the disease is chronic myelomonocytic leukemia.