Transcriptome datasets of hematopoietic stem and progenitor cells from three AML mouse models Tet2−/−;Flt3-ITD, Tet2−/−;Tet3−/− and Tet2−/−;Ins2Akita/+ were utilized here for further prioritization of essential genes. This evidence concerns the gene TET3 and acute myeloid leukemia.