Along with CDKN2A, other INK4 family members, CDKN2B, CDKN2C, and CDKN2D, also showed a good ability to distinguish tumor from normal tissue, particularly CDKN2C, suggesting that they can be used as biomarkers for the screening, diagnosis, and prognosis prediction of HCC. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.