CDKN2A is highly expressed in HCC and associated with prognosis and infiltrating levels of immune cells [12]; however, the role of the other INK4 family members, namely CDKN2B, CDKN2C, and CDKN2D, in the diagnosis, prognosis, and immune regulation of HCC is unclear. Here, CDKN2D is linked to hepatocellular carcinoma.