Swimming exercise ameliorated depression-like behaviors induced by Asmt knockout, including increased percentage of sucrose preference in SPT (P<0.01, Figure 1A), struggling time in FST (P<0.05, Figure 1C) and poking number in OFT (P<0.01, Figure 1D), as well as decreased immobility time in FST (P<0.05, Figure 1B). Here, ASMT is linked to major depressive disorder.