PIDD1 and major depressive disorder: In order to further investigate the roles of identified DEGs in the development of depression, then we constructed another network (Figure 6F) among Asmt, brain-derived neurotrophic factor (Bdnf), MT receptors (Mtnr1a and Mtnr1b), identified DEGs (Eps8l1, Plcb2, Chek1, Cdkn1a, Itpr2, Mdm4, Pidd1, Hspa1b), the first-order neighbors of Eps8l1 (Cask, Sos1, Abi1) and Plcb2 (Gna11).