Collectively, these data suggest that while MITF activates genes via its canonical E‐box recognition motif, it may repress genes either directly or indirectly through long‐range interactions by preventing regulation by a range of transcription factors known to be active in MITFLow melanomas such as AP1 (Riesenberg et al., 2015; Verfaillie et al., 2015) and NFκB (Ohanna et al., 2011). Here, MITF is linked to melanoma.