Notwithstanding previous attempts to define the repertoire of genes regulated by MITF (Hoek, Schlegel, et al., 2008; Louphrasitthiphol, Siddaway, et al., 2020; Strub et al., 2011; Verfaillie et al., 2015; Webster et al., 2014), the existing signatures and known targets are not sufficient to explain the broad and key role of MITF in melanocyte development, melanoma progression, and drug resistance. This evidence concerns the gene MITF and melanoma.