MITF and melanoma: Importantly, MITF has emerged as a key driver and marker of melanoma phenotype, and its mRNA expression and translation is suppressed by a wide range of microenvironmental cues including hypoxia (Cheli et al., 2012; Louphrasitthiphol et al., 2019; Widmer et al., 2013), nutrient limitation (Falletta et al., 2017; Ferguson et al., 2017) and inflammatory signaling (Falletta et al., 2017; Riesenberg et al., 2015), many of which converge on translation reprogramming via phosphorylation of eIF2α (Falletta et al., 2017).