Our analysis of several GEO datasets (GSE12452, GSE2109, and GSE9844) showed that TRPM7 mRNA expression was upregulated in HNSCC, including NPC, tongue SCC, and hypopharyngeal SCC; high TRPM7 expression was associated with poor prognosis in HNSCC patients (Figures 1, 2). Here, TRPM7 is linked to head and neck squamous cell carcinoma.