TET2, ZBTB4, MBD4, ZBTB38 and NTHL1was significantly down-regulated in tumor tissues, while TET3, SMUG1, MBD1, TET1, UNG, DNMT3A, MECP2, DNMT3B, DNMT1 and UHRF1 was significantly up-regulated in tumor tissues (Figure 1D). The gene discussed is ZBTB4; the disease is neoplasm.