In agreement with VEP prediction, de-novo high impact editing modifications occurred in AIFM1 (Xq26.1, HGNC Id: 8768) in CCM-ECs1 and in ARHGAP26 (5q31.3, HGNC Id: 17,073), CDK1 (10q21.2, HGNG Id: 10q21.2) and SPP1 (4q22.1, HGNC Id: 11,255) in CCM-ECs2. The gene discussed is SPP1; the disease is cerebral cavernous malformation.