Here, when the system reaches the acidic environment of lysosomes in T cells, ZIF-8 degrades and releases perforin and granzyme B, which remain stored in the lysosome until the T-cell receptor is activated by the major histocompatibility complex of tumor cells.147 All in all, this allows the creation of super-cytotoxic lymphocytes. The gene discussed is PRF1; the disease is neoplasm.