CD44 and cancer: For example, the work by Qhattal and Liu investigated CD44-mediated uptake of hyaluronan-grafted liposomes in cancer cells by determining the effect of hyaluronan molecular weight, grafting density and CD44 receptor density on particle endocytosis.121 In this case, particle-CD44 binding and subsequent trafficking were impacted by the grafting density and hyaluronan chain length – showing that their hyaluronan-coated particles trafficked to low pH organelles.