INS and Insulin resistance: BMI = body mass index; DBP = diastolic blood pressure; FPG = fasting plasma glucose; FPI = fasting plasma insulin; TGL = fasting serum triglycerides; HbA1c = glycosylated hemoglobin; HOMA-IR = homeostatic model assessment for insulin resistance; M = mazindol treatment; MM = mazindol-metformin treatment; SBP = systolic blood pressure; WC = waist circumference.