Furthermore, we not only examined the biological role of ANXA1 in GBM cell proliferation, migration, and invasion under ANXA1 knockdown, but we were also the first, to our knowledge, to elucidate the possible mechanism that ANXA1 affects NF‐κB transcriptional activity, and thus, IL‐8 expression to mediate GBM immune escape. This evidence concerns the gene NFKB1 and glioblastoma.