This study aimed to elucidate the role of ANXA1 in GBM biology, including GBM cell proliferation, invasion, migration and apoptosis, and to provide new insights into the mechanism of ANXA1‐mediated tumorigenicity by which ANXA1 increases IL‐8 expression through NF‐κB (p65) activation, thereby affecting DC functions and finally leading to immune escape in GBM. Here, NFKB1 is linked to glioblastoma.