circRNAs are involved in SLE pathogenesis and development80, 81; for example, T cells from patients with SLE express reduced levels of hsa_circ_0045272, which has binding sites for hsa‐miR‐6127, resulting in downregulation of two mRNAs, NM_015177 (DTX4) and NM_003466 (PAX8).82 The gene discussed is DTX4; the disease is systemic lupus erythematosus.