For example the genes in our EPIMISC signature showed a significant enriched Gene Ontology (GO) biological processes (hypergeometric test, adjusted P < 0.05) of “regulation of natural killer cell mediated immunity (GO:0002715)” and “peptide antigen assembly with MHC protein complex (GO:0002501)” that were not observed in critically-ill COVID-19 adults.12 Here, HLA-C is linked to COVID-19.