Some of the identified MIS-C epigenetic targets, such as AIM2 and PM20D1, and the EPIMISC signature overall, are also present in some severe adult COVID-19 cases, confirming that both processes (MIS-C in pediatrics and severe acute respiratory distress syndrome in adults) are inflammatory post-infectious complications and probably could be differently treated than the initial phase of the viral infection. This evidence concerns the gene AIM2 and viral infectious disease.