Compared with females, males had significantly higher age, BMI, SBP, DBP, ALT, AST, ZJU index, Cr, urea, UA, LDL-C, non-HDL-C, TG, ApoB, glucose, HbA1c, and prevalence of hyperglycemia and hypertension, whereas lower eGFR, HDL-C, and ApoA1 levels (all p < 0.001). The gene discussed is APOA1; the disease is Hypertension.