Liao et al. (12) and Mikael et al. (32) both showed that Hcy could inhibit the hepatic synthesis and expression of ApoA1, the main apolipoprotein of HDL-C, which explained not only the inverse association of Hcy with ApoA1 and HDL-C but also the Hcy-induced ASCVD risk. The gene discussed is APOA1; the disease is atherosclerosis.