IFNG and hypertensive disorder: Indirectly they also cause activation of the adaptive immunity via the Th1 response or the humoral/antibody Th2 response, triggering further secretion of potent pro-inflammatory cytokines like interleukin (IL)-6, interferon (IFN)-γ, and IL-17, in turn contributing to the hypertension pathology (Mikolajczyk and Guzik, 2019).