ANG II has also been implicated as a crucial mediator of immune and inflammatory processes in hypertension (Ruiz-Ortega et al., 2000; Benigni et al., 2010) and hence ANG II infusion is a popular and consistent in vivo animal model for inducing hypertension with an inflammatory component in preclinical research (Schiffrin and Touyz, 2003). Here, AGT is linked to hypertensive disorder.