Another mechanism involves the increased production of endothelin-1, along with hyperactivation of the RAS increasing oxidative stress, which has been known to promote SLE hypertension (Kuryliszyn-Moskal et al., 2008; Mathis et al., 2012; Shah et al., 2014; Munguia-Realpozo et al., 2019). This evidence concerns the gene EDN1 and hypertensive disorder.