For example the drug Etanercept, which blocks TNF-α, reduced blood pressure in ANG II-induced hypertension (Guzik et al., 2007) and an autoimmune model of chronic inflammation (Venegas-Pont et al., 2010), but not in salt-dependent hypertension (Elmarakby et al., 2008). This evidence concerns the gene AGT and hypertensive disorder.