Furthermore, knockout models such as B cell activating factor (BAFF) receptor knockout (BAFF-R−/−) mice or depletion of B and/or T cell activity using treatments like rituximab or mycophenolate mofetil blunt experimental hypertension in rodents (Herrera et al., 2006; Zheng et al., 2010; Chan et al., 2015; Taylor and Ryan, 2017; Taylor et al., 2018). Here, TNFRSF13C is linked to hypertensive disorder.