EGFR and Autoimmunity: Hancock et al. (2020b) reported that miR-US5-2 directly downregulated epidermal growth factor receptor (EGFR) adaptor protein GAB1, which regulated EGR1 and UL138 expression by affecting downstream MEK/ERK signaling, and then played a key role during reactivation from latency. miR-US25-1-3p significantly upregulated in the reactivation autoimmune patients than others and exhibited an obvious shift-switch from latency to reactivation (Zhou et al., 2020).