As is the case with DLGAP1 exon 20 in the white matter glial cells, the splicing abnormality in these events, such as CAMKK2 exon 16, was more apparent in the DM1 spinal motor neurons compared with the other CNS cells or not apparent in the other CNS cells, which also indicates the cell type-dependent variation of splicing misregulation in DM1. This evidence concerns the gene CAMKK2 and myotonic dystrophy type 1.