It turned out that 5 genes (CD14, CMKLR1, HCK, ITGB2, and PTAFR) were consistently associated with the prognosis of melanoma, both in primary and metastasized conditions (Table 1); thus, a prognosis model was generated with these 5 genes through multifactor Cox regression based on the survival data available in TCGA-SKM (Figure 3). This evidence concerns the gene HCK and melanoma.