Liu et al. (2015) reported that hesperetin improved depression and anxiety -like behaviors in diabetic rats via activation of Nrf2/ARE pathway. In addition, among 57 chemical markers of BLO, there are also 6 compounds with neuroprotective effects, which may also play a role in the anti-depression of BLO, namely sopimpinellin (Hao et al., 2019), DL-stachydrine (Cheng et al., 2020), lipoamide (Hou et al., 2019), ethyl ferulate (Scapagnini et al., 2004; Cunha et al., 2019), (+)-catechin (Bernatoniene and Kopustinskiene, 2018; Pervin et al., 2019), and myristicin (Ha et al., 2020). The gene discussed is NFE2L2; the disease is major depressive disorder.