REN and diabetes mellitus: DRAs related to treatment safety most frequently involved Antithrombotic agents, Antineoplastic agents, Diuretics, Corticosteroids for systemic use, and Beta blocking agents, while DRAs related to treatment effectiveness most frequently involved Diuretics, Antithrombotic agents, Drugs used in diabetes, Agents acting on the renin-angiotensin system, and Lipid modifying agents.