Additionally, the level of FXR in liver tissue of patients with severe hepatic fibrosis was decreased and the level of miR-199a-3p was increased, while the expression of miR-199a-3p was inhibited after activation of FXR, which further inhibited the proliferation of HSCs and alleviated hepatic fibrosis. The gene discussed is NR1H4; the disease is Hepatic fibrosis.