However, PNS administration dramatically raised the p-Akt/Akt, p-mTOR/mTOR, and p-p70S6K/p70S6K ratios in a dose-dependent manner, suggesting that Akt/mTOR/p70S6K pathway might participate in the protective mechanisms of PNS against cerebral ischemia injury. This evidence concerns the gene AKT1 and brain ischemia.