A study proved the cytotoxic effects of allicin purified from fresh garlic cloves on HCT116 colon cancer cells and showed that allicin induced apoptosis via a mechanism associated with transactivation of the transcription factor Nrf2 and was characterized by decreasing Bcl-2 levels, increasing Bax levels, enhancing hypodiploid DNA content, and enhancing the ability to release cytochrome C from mitochondria to the cytosol (Bat-Chen et al., 2010). Here, NFE2L2 is linked to colonic neoplasm.