Based on the fact that DATS can inhibit the growth of tumor cells in vitro by blocking the cell cycle, destroying the cell microtubule network, increasing caspase-3 activity, and inducing apoptosis, the researchers conducted in vivo experiments, and the results showed that DATS can also suppress tumor growth in nude mice bearing HCT-15 xenografts (Hosono et al., 2005). The gene discussed is CASP3; the disease is neoplasm.