Curcumin can inhibit Wnt/β-catenin signaling in diabetic rats and attenuate the reaction of superoxide, TGF-β1, and fibronectin activity in renal mesangial cells by high glucose and alleviate the accumulation of ECM in diabetic nephropathy (Ho et al., 2016). This evidence concerns the gene TGFB1 and diabetic kidney disease.