Previous studies have suggested that total ginsenosides have a profound protective effect in acute myocardial ischemia, and ginsenosides can simultaneously inhibit TGF-β1/Smad, NF-κB conduction, activation of Nrf2-ARE conduction to attenuate renal fibrosis (Gao et al., 2021). Here, TGFB1 is linked to renal fibrosis.