Whereas other compounds halted the EMT process/metastasis through distinct mechanisms, for instance, jatrorrhizine suppressed the EMT process through Wnt/β-catenin signaling in a cell, and xenograft mice model (Wang et al., 2019c); coptisine reduced cancer metastasis risk associated with PI3K/AKT signaling pathway in vivo and in vitro (Li et al., 2014; Huang et al., 2017; Cao et al., 2018); palmatine inhibited the prostate cancer cell invasion through rpS6/NFкB/FLIP (Hambright et al., 2015). The gene discussed is AKT1; the disease is Familial prostate cancer.