Moreover, to clarify the effects of AEDs on the mRNA levels of epilepsy‐related and synapse‐related proteins in Cdh5‐CreERT2;CDK5f/f mice, the mRNA levels of Btaf1, Phka1, Nav1, Bdnf, Magt1, and Grin1 were confirmed by qRT‐PCR. This evidence concerns the gene CDH5 and epilepsy.