Moreover, a genetically engineered model is required to specifically knock out DJ-1, using either DJ-1 conditional knockout mouse model [30] or establishing DJ-1-deleted sorafenib-resistant HCC cells via CRISPER, to provide the direct evidence that DJ-1 is vital in sorafenib resistance in HCC and DJ-1/FGFR1 signaling is a potent target. Here, FGFR1 is linked to hepatocellular carcinoma.