WNK2 and Netherton syndrome: With the elucidation of the underlying genetic variants causing NS, numerous studies have revealed that NS and NS-like disorders are ‘RASopathies’ or ‘RAS/mitogen-activated protein kinase (MAPK) syndromes’ because they share aberrant signaling through the RAS/MAPK pathway that controls cell proliferation, differentiation and survival (Aoki et al., 2008; Tidyman and Rauen, 2009).