The OR of gallstones was 1.11 (95% CI: 1.03, 1.19; p = 0.008) for one standard deviation increase in genetically predicted GDF-15 levels in a univariate model, and the effect estimate remained significant (OR = 1.10, 95% CI: 1.03, 1.19; p = 0.027) after adjustment for additional full list of covariates. The gene discussed is GDF15; the disease is gallstones.