Our study showed that among the SNPs associated with loci in patients with leprosy in southern China, one SNP (rs75324027) is located in the intergenomic region between non-HLA-DRB1 and HLA-DQA1, and by calculation, the LD between RS9270650 (observed by Wong et al.)and RS75324027 is 0.16. This evidence concerns the gene HLA-DRB1 and leprosy.