When characterized as continuous variables, IL-6 responses to S. enterica and E. coli were generally opposite in effect, with the IL-6 response to S. enterica inversely associated with respiratory ID (for any respiratory ID: HR: 0.68; 95% confidence interval [CI]: 0.54, 0.86; P: 0.001; for pneumonia: HR: 0.68; 95% CI: 0.51, 0.92; P: 0.011; for URTI: HR: 0.70; 95% CI: 0.54, 0.89; P: 0.004) and the IL-6 response to E. coli positively associated with gastrointestinal ID (HR: 1.44; 95% CI: 1.05, 1.99; P: 0.022). The gene discussed is IL6; the disease is pneumonia.