HNF1B and multicystic dysplastic kidney: For example, we developed a disease model for multicystic dysplastic kidney (MCDK) using our iUB organoids and heterozygous HNF1β-knockout hiPSC lines established by the CRISPR-Cas9 system (Bellanne-Chantelot et al., 2004; Heidet et al., 2010; Nakayama et al., 2010; Mae et al., 2020).