We then analyzed genetic alterations in the EXO1 gene based on samples from 737 HCC patients from the following three datasets: MSK, Clin Cancer Res 2018 (n = 127) (Harding et al., 2019); AMC, Hepatology 2014 (n = 231) (Ahn et al., 2014), and TCGA, Firehose Legacy (n = 379). This evidence concerns the gene EXO1 and hepatocellular carcinoma.