Interestingly, Huang et al. (2017) found a 53-aa-long conserved peptide encoded by lncRNA HOXB-AS3 in colorectal cancer (CRC) cells, which could inhibit the growth of CRC cells by binding to the heterogeneous nuclear ribonucleoproteins A1 (hnRNP A1) to mediate the cancer metabolic reprogramming process (Figure 2D). The gene discussed is PDS5B; the disease is colorectal carcinoma.