In addition, loss of the LINC00961/SPAAR locus was found to affect development, myocardial dynamics, and myocardial infarction cardiac response in mice (Spiroski et al., 2021), which suggests that LINC00961/SPAAR contributes to growth and development as well as basal cardiovascular function in adulthood, thus mitigating the risk of myocardial infarction. Here, SPAAR is linked to myocardial infarction.