Given that immune checkpoints play a crucial role in tumor immunosuppression, we analyzed the correlation between AC087588.2 expression and that of the immune checkpoint-related genes of CD274, CTLA4, HAVCR2, LAG3, PDCD1, PDCD1LG2, TIGIT, and SIGLEC15 in LUAD using Pearson’s correlation analysis. This evidence concerns the gene SIGLEC15 and neoplasm.