CD4 and asthma: Tsitsiou et al. (Tsitsiou et al., 2012), using transcriptome analysis, showed that severe asthma is associated with the activation of circulating CD8+ T cells but not CD4+ T cells, which is correlated with the changes in the expression of miR-146a/b and miR-28-5p as well as 167 different lncRNAs that might regulate CD8+ T-cell function.