In addition, Li et al. (Li et al., 2019b) found that MIR155HG regulated M1/M2 macrophage polarization in COPD by regulating IL-1β, IL-10, IL-12, and TNF-α expression, suggesting that MIR155HG might be involved in the development of COPD. The gene discussed is MIR155HG; the disease is chronic obstructive pulmonary disease.