HOXA-AS2 and chronic obstructive pulmonary disease: HOXA-AS2 was downregulated in lung tissues from COPD patients, and the downregulation of HOXA cluster antisense RNA 2 (HOXA-AS2) suppresses CSE-induced human pulmonary microvascular endothelial cells (HPMECs) proliferation via Notch1 signalling in vitro (Zhou et al., 2020a).