A number of lncRNAs including myocardial-infarction‐associated transcript (MIAT) (Gu et al., 2022), nicotinamide nucleotide transhydrogenase-antisense RNA1 (NNT-AS1) (Mei et al., 2020), XIST (Chen et al., 2021), and TUG1 (Gu et al., 2019) are upregulated in CSE-induced human bronchial epithelial cell line (16HBE) and interact with the miR-29c-3p/HIF3A axis, the miR-582-5p/FBXO11 axis, the miR-200c-3p/early growth response 3 (EGR3) axis, and the miR-145-5p/dual-specificity phosphatase 6 (DUSP6), respectively, to participate in CSE-induced 16HBE cell apoptosis and inflammation. The gene discussed is EGR3; the disease is infarction.