The upregulation of LINC00612-inhibited cell apoptosis, inflammation, and oxidative stress in HPMECs induced by CSE positively regulated Notch signalling by sponging miR-31-5p, indicating that LINC00612/miR-31-5p/Notch axis could function as a potential biomarker and treatment target for COPD in the future. The gene discussed is LINC00612; the disease is chronic obstructive pulmonary disease.