We and others have recently demonstrated that excessive activation of the STING1 pathway contributes to cytokine storms, systemic coagulation, and multiple organ failure in experimental models of sepsis (Ge et al., 2019; Heipertz et al., 2017; Hu et al., 2019; Kang et al., 2017; Ning et al., 2020; Wu et al., 2020). The gene discussed is STING1; the disease is Sepsis.