Current studies showed that antitumor mechanisms of IFN mainly included inhibiting the activity of endothelial cells, which mediated tumor angiogenesis, and enhancing the immunogenicity of immune cells, including T cells, NK cells, DC cells, and macrophages, which showed the close relationship between IFN expression and immune status of cancer, thus influencing the prognosis of cancer patients [19–22]. Here, IFNA1 is linked to neoplasm.