LT-HCC patients had significantly higher percentage of senescent-like T and B cells compared to LT-no-HCC (%CD8+CD28-CD57+: 11.06 (6.24-25.16) vs 5.92 (3.54-10.97), p=0.006; %CD4+CD28-CD57+: 3.80 (1.36-14.03) vs 1.80 (0.48-3.41), p=0.002; %CD19+CD27-IgD-: 12.20 (6.28-17.67) vs 6.59 (4.24-12.50), p=0.019) (Figure 1C). The gene discussed is CD4; the disease is hepatocellular carcinoma.