Considering that these mutated genes have regulatory relationships and affect the occurrence of LUAD through common pathways, we subsequently performed gene interaction analysis for these mutated genes and constructed a gene network for smoking-related LUAD centered on genes known to be high frequency mutated in LUAD, such as KRAS and TP53. Based on the results of the literature search, most of these smoking-related core genes (CDKN2A, EGFR, KRAS, TLR4, TP53, SPTA1, and STK11) we identified have been reported in many studies for their association with lung cancer. Here, EGFR is linked to lung cancer.