The higher serum Cathepsin D, IgE, EGFR, MMP-9, vWF, haptoglobin, and p-Tau181 levels were associated with severity of memory impairment (as indicated by lower MMSE and MoCA scores, and higher ADL, CDRglobal, and CDRsob scores). The gene discussed is IGHE; the disease is memory impairment.