The increase in epithelial permeability was reported to be significantly associated with the severity of low-grade duodenal inflammation and protein expression of occludin was correlated with duodenal eosinophil counts (23), highlighting the importance of the duodenal barrier in potentiating the FD inflammatory phenotype as well as the role eosinophils may play in contributing to the dysfunction of the duodenal barrier. The gene discussed is OCLN; the disease is Fabry disease.