GSDME and colorectal cancer: Several studies have shown that the pyroptosis core genes behave differently in different tumors, with GSDMC, GSDMD, and GSDMB acting as oncogenes in colorectal cancer, small-cell lung cancer, and breast cancer, respectively [41–43], while GSDME acts as a tumor suppressor in a variety of cancers [15, 44, 45].