Indeed, nonameric and hexameric TNFR2-specific scTNF variants showed therapeutic activity in murine disease models to treat GvHD (8), collagen-induced arthritis (9, 10), experimental autoimmune encephalomyelitis (11, 12) and T cell transfer colitis (13). This evidence concerns the gene TNFRSF1B and experimental autoimmune encephalomyelitis.