It could be seen that MLKL (n=521), TNF-alpha (n=332), NF-κB (n=315), RIPK3 (n=233), and RIPK1 (n=155) were the most studied molecules; cell-death (n=1211), apoptosis (n=1,104), necroptosis (n=885), necrosis (n=557), inflammation (n=443), and oxidative stress (n=273) were the most mentioned pathological process; and cancer (n=170), ischemia/reperfusion injury (n=110), infection (n=50), carcinoma (n=32), and Alzheimer’s disease (n=31) were the most studied diseases in necroptosis studies. The gene discussed is MLKL; the disease is early-onset autosomal dominant Alzheimer disease.