On the other hand, there is also evidence that necroptosis may promote carcinogenesis by inducing adaptive immunosuppression; for instance, RIPK1 is overexpressed in glioblastoma, lung cancer, and pancreatic ductal adenocarcinoma (PDAC) (74, 75), and RIPK3 and MLKL are highly expressed in PDAC (75, 76). This evidence concerns the gene RIPK1 and pancreatic ductal adenocarcinoma.