On the other hand, there is also evidence that necroptosis may promote carcinogenesis by inducing adaptive immunosuppression; for instance, RIPK1 is overexpressed in glioblastoma, lung cancer, and pancreatic ductal adenocarcinoma (PDAC) (74, 75), and RIPK3 and MLKL are highly expressed in PDAC (75, 76). The gene discussed is RIPK3; the disease is pancreatic ductal adenocarcinoma.