RIPK1 and lung cancer: On the other hand, there is also evidence that necroptosis may promote carcinogenesis by inducing adaptive immunosuppression; for instance, RIPK1 is overexpressed in glioblastoma, lung cancer, and pancreatic ductal adenocarcinoma (PDAC) (74, 75), and RIPK3 and MLKL are highly expressed in PDAC (75, 76).