We found that after the knockdown of DYM gene, IL-6, CCL2 cytokines in the supernatant were down-regulated in the co-culture system of bladder cancer cells and macrophages, thereby reducing the recruitment of macrophages(CCL2 effection) and the transformation of macrophages into M2 macrophages(IL-6 effection). The gene discussed is IL6; the disease is urinary bladder carcinoma.