Using a branched expression analysis modelling approach, we identified a set of genes that were regulated in a branch-dependent manner based on the trajectory analysis (Supplementary Figure 4E), in which CRCT1 was upregulated in the HPV- cells and appeared to play a significantly negative role in the survival prognosis of cervical cancer patients (Supplementary Figures 4F–H). The gene discussed is CRCT1; the disease is cervical carcinoma.