Also, it was found that there was a significantly enhanced VEGFA and TNFRSF10B/DR5 signaling association with macrophages interacting with HPV- types 0 and 2 tumor cells, which was confirmed by tissue staining and appeared to play a significantly negative role in the prognosis of cervical cancer patients (Figures 5C–F). The gene discussed is TNFRSF10B; the disease is cervical carcinoma.