This was achieved by evaluating the spines of mice heterozygous (N153S) for the Sting1em1Jmin mutation that constitutively activates STING without altering STING expression levels and STING-\- mice to assess the contribution of STING to SASP onset and intervertebral disc degeneration (24, 29). This evidence concerns the gene STING1 and Intervertebral disk degeneration.