Recently, a rat model of vertebral inflammation-induced intervertebral disc degeneration, where lipopolysaccharide (LPS) was introduced into vertebral defects, showed a degenerative phenotype marked by cartilaginous endplate defects, immune cell infiltration, and higher levels of cGAS, STING, TBK1, and IRF3 (27). The gene discussed is STING1; the disease is Intervertebral disk degeneration.