These genes include CDKN1A and CDKN1B (cell cycle arrest); GLUT1, PGK1 and LDHA (anaerobic metabolism, lactic acid production and mitochondrial dysfunction); EPO, VEGF, ARNT, CITED2, TDGF-β and TfR (oxygen transport, neo angiogenesis and platelet formation); and TGFB2 (tumor growth, immunosuppression and cell migration) (Figure 1). This evidence concerns the gene VEGFA and neoplasm.