Hypoxia alters the immune crosstalk by affecting the tumor-associated macrophages (TAMs) that potentiate immunosuppression by inhibiting immune cell recruitment, produce IL-6/IL-10 inducing PD-L1 expression on T cells, TNF-α affecting MAPK inhibitors efficacy against melanoma in human and mouse model, and increase metastasis and angiogenesis (41–43). The gene discussed is IL6; the disease is melanoma.