HLA-B and HIV infectious disease: However, the association of ERAP2 with this disease appears independent of the presence of HLA-B*27, in contrast to the ERAP1 association in epistasis with HLA-B*27 (36), which may speak to other functions of ERAP2 in addition to epitope production (see ERAPS in the Modulation of Cytokine-Mediated Signaling, in the Regulation Of Blood Pressure, and in Sars-Cov-2 and HIV Infection).