Thus, ERAP2 may affect protection against HIV in this way in addition to its role in immunopeptidome production, contribution to the regulation of hypertension, and a possible effect of interactions of truncated ERAP2/Iso3 with ERAP1 or with untruncated ERAP2/Iso1 (42, 43, 46). The gene discussed is ERAP2; the disease is hypertensive disorder.