Though meningiomas are classically attributed to NF2 disruptions, sequencing studies have identified mutations in PI3KCA, AKT1, SMO, KLF4, TRAF7, POLR2A, CDKN2A, BAP1, and the DREAM complex.10–16 Familial meningioma syndromes have been attributed to mutations involving the SWItch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex components SMARCB1 and SMARCE1. Here, NF2 is linked to meningioma.