An analysis of promoter methylation in NF2 altered vs wildtype yielded 98 gene promoters that were hypermethylated in NF2 altered meningiomas relative to wildtype tumors and 325 gene promoters that were hypomethylated in NF2 wildtype tumors (Figure 4a; Supplementary Figure 4). The gene discussed is NF2; the disease is meningioma.