AKT1 and cancer: Mutations of FOXC1 in humans lead to severe craniofacial abnormalities and FOXC1-mutant mice exhibit severe cranial abnormalities including the absence of forebrain dura.54 Additionally, FOXCUT and FOXC1 have been shown to form mRNA-lncRNA complex that leads to upregulation of the FOXC1/PI3K/AKT pathway and play a role in a diverse set of cancers.